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Wednesday, May 6, 2020

Ensuring Quality of Piper longum (Pippali) on high demand to manufacturing medicines


Herbal remedies have become popular, due in part to the lower risk of adverse reactions. Thousands of plants have been used traditionally to treat various diseases. Among them, species of the genus Piper are important medicinal plants used in various systems of medicine. The Piper longum fruit has been used in traditional medicine, including the Ayurvedic system of medicine due to its high medicinal values. In Ayurvedic formulary of India, it is reported to use Pippali in more than 300 formulations.

The fruit (Spike) of Pippali (Piper longum Linn.) is one of the prime Rasayana (rejuvenator) drugs in Ayurveda and is widely used to treat various diseases especially for the treatment of respiratory disorders. Several biological activities like immunostimulatory, anti-ulcer, anti-amebic, anti-oxidant, hepato-protective, asthma, constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, chronic malaria, viral hepatitis, respiratory infections, stomachache, bronchitis, diseases of the spleen, cough, and tumors  and anti-inflammatory activities were reported on the fruit of this plant. 

Long pepper (Pippali) as sold in India appears to be derived from two or three species, including one, which Indonesian. Indian long pepper is a product either of Piper longum or Piper peepuloides, while the Indonesian and Java Long Pepper imported from Malaysia is from Piper retrofractum. The products of these species are used for the same purposes. In India, the main source of supply being Assam, West Bengal, Uttar Pradesh, and from neighboring country Nepal. India also imports the long pepper from Malaysia and Singapore.  


There are several varieties of Piper longum fruits such as Murshidabad (Asli), Shillong (Savali), Coach Behar & Assam (Bodki), Coach Behar & Assam (Gol), Purnea, Central Bengal and Indonesia (Piper retrofractum) is commonly available in the Indian market either in separate or in mixed form. However, we have already set up our mind to categories them as Chhoti Pippali (small sized), Badi Pippali (long sized) and Gol pippali (Round shaped). All the above said varieties are used for similar therapeutic purposes but Chhoti Pippali (Savali) is more preferred by physicians. It is a well-known fact that the Pippali is one of the most important drugs in the treatment of Tamaka Shwasa (bronchial asthma).  

The worldwide spread corona is also reported to infect the respiratory tract and thus, there is a high demand of the Pippali to manufacture drug as it is one of the important ingredients to prepare formulation for treating respiratory disorders. As we know that in preparation of compound formulation, all the ingredients must require to take an effective batch of medicines. If any ingredient not available, the production of medicine will be stopped. In my opinion, when all varieties of Piper longum have similar therapeutic value, we may consider the situation and not to stick a particular variety while accepting the same in the manufacturing of medicines.   

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